Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome.

Blesso CN, Andersen CJ, Barona J, Volek JS, Fernandez ML.

Source

Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.

Abstract

OBJECTIVE:

We investigated if daily egg feeding, along with carbohydrate restriction, would alter lipoprotein metabolism and influence atherogenic lipoprotein profiles and insulin resistance in men and women with metabolic syndrome (MetS).

METHODS:

In a randomized, single-blind, parallel design, participants consumed either 3 whole eggs/day (EGG, n=20) or the equivalent amount of yolk-free egg substitute (SUB, n=17), as part of a moderately carbohydrate-restricted diet (25%-30% energy) for 12 weeks. Plasma lipids, apolipoproteins (apos), oxidized LDL (oxLDL), cholesteryl ester transfer protein (CETP) and lecithin-cholesterol acyltransferase (LCAT) activities were assessed at baseline and week 12. Lipoprotein particle concentrations and sizes were measured by nuclear magnetic resonance spectroscopy.

RESULTS:

Atherogenic dyslipidemia improved for all individuals as evidenced by reductions in plasma triglycerides, apoC-III, apoE, oxLDL, VLDL particle diameter, large VDL, total IDL, small LDL, and medium LDL particles (P<0 .05=".05" activity="activity" all="all" and="and" both="both" compared="compared" consuming="consuming" diameters="diameters" egg="egg" for="for" furthermore="furthermore" greater="greater" group="group" hdl-cholesterol="hdl-cholesterol" hdl="hdl" however="however" in="in" increased="increased" increases="increases" individuals.="individuals." insulin="insulin" large="large" lcat="lcat" ldl="ldl" medium="medium" only="only" over="over" p="p" particles="particles" plasma="plasma" reduced="reduced" reductions="reductions" resistance="resistance" sub="sub" the="the" there="there" those="those" time="time" to="to" total="total" vldl="vldl" were="were" while="while">

CONCLUSIONS:

Incorporating daily whole egg intake into a moderately carbohydrate-restricted diet provides further improvements in the atherogenic lipoprotein profile and in insulin resistance in individuals with MetS.

From: http://www.ncbi.nlm.nih.gov/pubmed/23021013