Protective effects of hawthorn leaves flavonoids on cardiac function in rats suffered from myocardial ischemia reperfusion injury

(CBA:518633)

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Min Qing,

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Bai Yuting,

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Wu Jiliang,

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Shu Sijie,

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Liu Tongyun

Department of Pharmacology,Xianning College.Xianning 437100,Hubei;China;;Department of Surgery,Xianning College.Xianning 437100,Hubei;China

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Zhongguo yao xue za zhi (Zhongguo yao xue hui : 1989)[2005, 40(7):515-517]

Type: Research article(lang: chi)

Abstract

Highlight Terms Gene Ontology(1)Diseases(1)Genes/Proteins(2)Species(1)Chemicals(3)

Myocadial ischemia reperfusion injury model was established by the ligation of left desending coronary artery for 30 min and reperfusion for 120 min in rats, and the influence of HLF on cardiac function, enzymes, lipid peroxide of myocardium was observed. HLF attenuated the declines of LVSP and ±dp/dt max and blood pressure in arterial, decreased Na~(+)-K~(+)-ATPase activity and the level of malondialdehyde(MDA), and increased superoxide dismutase(SOD) activity in ischemic myocardium. The results suggested that the effects of HLF on cardiac function in the process of ischemia reperfusion may be related to the mechanism of imporving energy metabolism, scavarging the oxygen free radicals and inhibiting production of free radical in ischemic myocardium.