Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery.
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Department of Pharmacology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu City, Shizuoka 431-3192, Japan. yapplel@hama-med.ac.jpAbstract
We have previously demonstrated that natto-extracts containing nattokinase (NK) inactivates plasminogen activator inhibitor type 1 and then potentiates fibrinolytic activity. In the present study, we investigated the effects of dietary supplementation with natto-extracts on neointima formation and on thrombolysis at the site of endothelial injury. Endothelial damage in the rat femoral artery was induced by intravenous injection of rose bengal followed by focal irradiation by transluminal green light. Dietary natto-extracts supplementation containing NK of 50 or 100 CU/body was started 3 weeks before endothelial injury and then continued for another 3 weeks. Intimal thickening in animals given supplementation was significantly (P<0 .01="" 0.03="" 0.06="" 0.09="" 0.12="" 0.16="" 100="" 50="" 8="" after="" although="" and="" animals="" arteries="" artery.="" at="" attached="" attributable="" be="" body="" both="" by="" center="" compared="" conclusion="" contrast="" control="" controls="" cu="" detached="" dietary="" effects="" endothelial="" enhanced="" femoral="" from="" group="" groups="" histologically="" hours="" in="" injury.="" injury="" intima="" intimal="" lumen="" lysis="" may="" media="" most="" mural="" natto-extracts="" near="" nk-treated="" nk="" observed="" of="" on="" p="" partially="" produced="" rat="" ratio="" reopened="" respectively.="" showed="" site="" supplementation="" suppressed="" surface="" the="" them="" these="" thickening="" those="" thrombi="" thrombolysis="" to="" treated="" vessel="" wall.="" wall="" walls.="" was="" were="" which="" with="" within="">
- PMID:
- 12850244
- [PubMed - indexed for MEDLINE]
