Benefits of Co Enzyme Q-10 Supplementation in Cardiovascular Health

From: http://www.holisticonline.com/Remedies/Heart/heart_CoQ10.htm

Co Enzyme Q10 (Co Q10) is a nutritional supplement used around the world as a heart energizer. Researchers found that in most of the cases of heart problems, there was an associated deficiency of CoQ10. On the corollary, all the well functioning hearts had an adequate amount of CoQ10 in the tissue. Furthermore, when supplemental CoQ10 was administered, the ailing hearts started showing signs of new life.

Experts say that adequate levels of CoQ10 is necessary for a well functioning system. When the levels of CoQ10 drops below optimum levels, disease takes over or already had done so.

What Is Co Q10?
Coenzyme Q-10, also known as ubiquinol-10, is a strong antioxidant. Like vitamins, it is a nutrient your body must take in to feed your cells so your body can operate at an optimum level. It is present in very small amounts in food, notably seafood, and is produced by all cells of the body. Japanese scientists have synthesized CoQ-10 into a raw material that is put into supplements.

Coenzymes are vital participants in many of the ongoing chemical reactions in our bodies that are the very essence of life. These chemical reactions provide our body's cells with energy from food. These chemical reactions allow cells to grow and divide, promoting growth in children and tissue repair in adults. They also allow our bodies to quickly build up a supply of infection-fighting immune cells when necessary.

Coenzyme Q10 is an essential ingredient in the body's production of energy and in the normal metabolism of fat and energy. It participates in biochemical reactions in our bodies that provide energy. It is of extreme benefit to sufferers of angina. It prevents the accumulation of fatty acids within the heart muscle by improving the conversion of fatty acids and other compounds into energy. When a person is suffering from cardiomyopathy and other kinds of heart failure, the supplements of coenzyme Q10 are thought to help the remaining muscle cells do their jobs more efficiently.

Coenzyme Q10 is manufactured by the body and stored in your organs: liver, kidneys and heart. It is believed that, in our body, the vitamins such as niacin, vitamin B6, vitamin B12, vitamin C and folate assist our body to convert the amino acid tyrosine to coenzyme Q10.

Many of the elderly may have increased CoQ10 requirements; the decline of CoQ10 levels that occurs with age may be partly responsible for the age-related deterioration of the immune system.

CoQ10 deficiency is common among individuals with heart disease. Heart tissue biopsies in patients with various heart diseases show a CoQ10 deficiency in fifty to seventy- five percent of cases. Furthermore, cardiovascular diseases, including angina, hypertension, mitral valve prolapse, and congestive heart failure, require increased tissue levels of CoQ10.

Is Coenzyme Q10 Good for Your Heart?
A growing number of nutrition oriented doctors say that supplements of Co Q10 are absolutely essential for people with heart failure. Co Q10 was said to have several patients who used it to live longer, more active lives, has saved some people who would otherwise have died waiting for donor hearts and has even allowed some to take their names off the transplant list.

Coenzyme Q10 and CHF
More than fifty major articles have been published in reputable medical journals worldwide in the last ten years on the use of coQ-10 for heart disease, primarily congestive heart failure.
Studies at the University of Texas at Austin showed that 75 percent of heart patients have severe deficiencies of CoQ10 in heart tissue compared with healthy individuals. They have also found that taking coenzyme Q-10 significantly benefited three-fourths of a group of elderly patients with congestive heart failure.

In one of the early studies, seventeen patients with mild congestive heart failure received 30 mg of CoQ10 per day along with conventional drug therapy. All patients improved, and nine (fifty-three percent) became asymptomatic after four weeks.

In another study, twenty patients with congestive heart failure, due either to atherosclerosis or high blood pressure, were treated with CoQ10 at a dosage of 30 mg/day for one to two months. Fifty-five percent of the patients reported subjective improvement, fifty percent showed a decrease in New York Heart Association (NYHA) classification, and thirty percent showed a "remarkable" decrease in chest congestion, as seen on chest X rays. Improvements recorded in patients given Co Q10 include increased cardiac output, stroke volume, cardiac index, and ejection fraction. CoQ10 produces an increased force of heart muscle contraction. The increase in the force of contraction produced by CoQ10 is similar to, but less potent than, digitalis. (Please note that the levels of Co Q10 used are not sufficient to show a marked effect for heart disease. That may explain the lackluster performance.)

Other studies have shown that CoQ10 significantly improves heart function in patients with CHF. In a Scandinavian double blind study of eighty CHF patients, participants were given either CoQ10 (100 mg/day) or a placebo for three months. The roles were switch. In other words, those taking CoQ10 were then given the placebo, and vice versa. The improvements noted with CoQ10 were significant; the results were more positive than those obtained from conventional drug therapy alone.

In another double-blind study, 641 CHF patients received either CoQ10 (2 mg/kg of body weight) or a placebo for one year. The number of patients who required hospitalization or who experienced serious consequences due to CHF was significantly reduced in the CoQ10 group compared to the placebo group.

In an Italian study involving a total of 2,664 patients with mild to moderate CHF, the participants 50 to 150 mg of Co Q10 orally per day for ninety days. (The majority of patients (seventy-eight percent) received 100 mg per day.) After three months of CoQ10 treatment, the percentages of patients with improvement in clinical signs and symptoms were as follows:
Sweating 79.8 percentEdema (fluid retention) 78.6 percentCyanosis (purple hue of skin) 78.1 percentPulmonary edema 77.8 percentHeart palpitations 75.4 percentVertigo 73.1 percentVenous congestion 71.8 percentSubjective arrhythmia 63.4 percentInsomnia 62.8 percentNighttime urination 53.6 percentShortness of breath 52.7 percentEnlargement of the liver area 49.3 percent

Improvement of at least three symptoms occurred in fifty-four percent of patients, showing a significantly improved quality of life with CoQ10 supplementation. The results also showed a low incidence of side effects: only thirty-six patients (1.5 percent) reported mild side effects attributed to CoQ10.

Extensive Japanese research has found that about 70 percent of patients improved on CoQ-10.
Several studies, mostly from Japan, have looked at coenzyme Q10's role in cardiovascular disease. They include two double-blind, placebo-controlled studies, which are considered the most reliable. The studies showed that coenzyme Q10 has clinical benefits for 70 percent of the patients having congestive heart failure. Coenzyme Q10 is normally concentrated in the heart muscle. Its levels drop when the heart begins to fail.

Reported research from the University of Connecticut School of Medicine showed that using CoQ10 by patients with congestive heart failure helped more than 70 percent of them. The data comes from treating thousands of patients. Researchers believe that the situations, Co Q10 hasn't helped is because of inadequate doses or using products with insufficient potency. They say that to be effective, you should take a dose of Co Q10 sufficient to substantially raise the blood levels of CoQ-10. If that happens, they believe that all heart patients would benefit from Co Q10 supplementation.

Co Q10 and Angina
Return of blood flow (reperfusion) after coronary artery bypass surgery greatly increases the risk of subsequent coronary artery disease because of oxidative damage to the vascular endothelium and myocardium. Coenzyme Q10 is believed to prevent such oxidative damage after bypass surgery or angioplasty. In one clinical study, forty patients undergoing elective surgery either served in the control group or received 150 mg of CoQ10 each day for seven days before the surgery. The concentrations of lipid peroxides and the enzyme creatine kinase, indicators of the myocardial damage, were significantly lower in patients who received CoQ10 than in the control group. The patients who received Co Q10 treatment also showed a statistically significant lower incidence of ventricular arrhythmias during the recovery period. The results clearly demonstrated that pretreatment with CoQ10 can play a protective role during routine bypass surgery by reducing oxidative damage.
In another study, twelve patients with stable angina pectoris were treated with CoQ10 (150 mg/day for four weeks). The frequency of anginal attacks was reduced by fifty-three percent compared to those receiving a placebo. In addition, there was a significant increase in treadmill exercise tolerance during CoQ10 treatment.

CoQ10 and Mitral Valve Prolapse
CoQ10 has also been shown to be quite helpful in cases of symptomatic mitral valve prolapse. In one study with 16 children, half received CoQ10 (2 mg/kg of body weight) each day for eight weeks, and the other half received a placebo. Heart function became normal in seven of the eight CoQ10-treated patients (87.5 percent), and in none (0 percent) of the placebo-treated patients. Relapse frequently occurred in patients who stopped taking the medication within twelve to seventeen months, but rarely occurred in those who took CoQ10 for eighteen months or more.)

CoQ10 and Cardiomyopathy
A deficiency of CoQ10 has been found in the blood and heart tissue of most patients who have cardiomyopathy. CoQ10 supplementation can raise CoQ10 levels and produce improvements in heart function as a result of improved energy production by the heart muscle.

Several double-blind studies in patients with various cardiomyopathies have shown significant benefit with CoQ10 supplementation. In one double-blind trial, daily administration of 100 mg of CoQ10 for twelve weeks increased cardiac ejection fraction significantly, reduced shortness of breath, and increased muscle strength. These improvements lasted as long as the patients were continuously treated. However, cardiac function deteriorated when CoQ10 was discontinued, indicating that individuals with cardiomyopathy may need to be on CoQ10 indefinitely. Seventy one patients out of 80 patients treated (eighty-nine percent) improved while taking CoQ10.
CoQ-10, is now a drug of choice in many countries. It is "routinely" given to patients with congestive heart failure in Israeli hospitals. Japanese doctors have used CoQ-10 for cardiac problems for more than thirty years. It is now among the top six pharmaceutical agents used in Japan. It is prescribed for heart failure in Italy.