Bupropion

From: 5 minutes consult

Dosing and Administration

MDD
Adults - PO

Immediate-release - 100 mg twice daily initially; may increase to 100 mg 3 times daily after 3 days (max daily dose, 450 mg; max single dose, 150 mg).

SR - 150 mg once daily initially; may increase to 150 mg twice daily as early as day 4 of therapy (max daily dose, 400 mg; max single dose, 200 mg).

XL - 150 mg once daily initially; may increase to 300 mg once daily as early as day 4 of therapy (max daily dose, 450 mg).

Aplenzin - 174 mg once daily in the morning initially; may increase to 348 mg once daily as early as day 4 of therapy (max daily dose, 522 mg) (174 mg tablet not currently marketed; expected launch in mid-year 2009).

Smoking Deterrent
Adults - Initial dose - PO 150 mg once daily for first 3 days, increasing to 150 mg
twice daily. Do not exceed 300 mg/day. Initiate treatment while patient is still smoking. Patient should set target date to quit smoking within the first 2 wk of treatment; continue treatment for 7 to 12 wk.Maintenance dose - PO Clinical data are not available regarding long-term treatment for smoking cessation. Whether to continue treatment beyond 12 wk must be determined for individual patients.
Combination treatment - PO Bupropion may be used in combination with a nicotine transdermal system for smoking cessation.