Common Antibiotics doses

Summmarized from 5 minutes consults


Amoxicillin: 1 g t.i.d. (adults); 80–90 mg/kg/d divided q8h (children)

Trimethoprim-sulfamethoxazole (TMP/SMX): 160/800 mg q12h in adults and 8–12 mg/kg/d of trimethoprim component divided q12h for children

Doxycycline: 100 mg PO b.i.d.

Amoxicillin-clavulanate (Augmentin): 875/125 mg q12h (adults); 30 mg/kg/d of
amoxicillin component divided b.i.d. in children

High-dose amoxicillin-clavulanate (Augmentin XR) b.i.d. in adults and Augmentin ES-600 in children (for both β-lactam and penicillin-binding protein resistance)

Cefpodoxime (Vantin): 200 mg q12h in adults and 10 mg/kg/d divided b.i.d. in children

Cefuroxime axetil (Ceftin): 250 mg q12hr in adults and 30 mg/kg/d divided q12h in children

Azithromycin (Zithromax): 500 mg on day 1 and 250 mg on days 2–5 in adults; 10 mg/kg on day 1 and 5 mg/kg on days 2–5 in children

Clarithromycin (Biaxin): 500 mg b.i.d. (regular) or 1,000 mg/d (extended release) in adults; 15 mg/kg/d divided b.i.d. in children

Levofloxacin (Levaquin): 750 mg/d for 5 days (adults only)

Cipro 500 mg bid


Avelox
Acute Bacterial Exacerbation of Chronic Bronchitis
Adults - IV / PO 400 mg/day for 5 days.

Acute Bacterial Sinusitis
Adults - IV / PO 400 mg/day for 10 days.

Community-Acquired Pneumonia
Adults - IV / PO 400 mg/day for 7 to 14 days.

Complicated Intra-Abdominal Infections
Adults - IV / PO 400 mg/day for 5 to 14 days.

Complicated Skin and Skin Structure Infections
Adults - IV / PO 400 mg/day for 7 to 21 days.

Conjunctivitis
Adults and Children 1 yr of age and older - Ophthalmic Instill 1 drop in affected eye(s) 3 times daily for 7 days.

Uncomplicated Skin and Skin Structure Infections
Adults - IV / PO 400 mg/day for 7 days.


Levaquin:
Acute Bacterial Exacerbation of Chronic Bronchitis
Adults - PO / IV 500 mg every 24 h for 7 days.

Acute Bacterial Sinusitis
Adults - PO / IV 500 mg every 24 h for 10 to 14 days or 750 mg every 24 h for 5 days.

Inhalational Anthrax (Postexposure)
Adults and Children more than 50 kg and 6 mo of age and older - PO/IV 500 mg every 24 h for 60 days.
Children less than 50 kg and 6 mo of age and older - PO 8 mg/kg (max, 250 mg/dose) every 12 h for 60 days.

Chronic Bacterial Prostatitis
Adults - PO / IV 500 mg every 24 h for 28 days.

Community-Acquired Pneumonia
Adults - PO / IV 500 mg every 24 h for 7 to 14 days, or 750 mg every 24 h for 5 days.

Complicated UTIs; Acute Pyelonephritis
Adults - PO / IV
Complicated UTIs caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis, and acute pyelonephritis caused by E. coli, including cases with concurrent bacteremia - 750 mg every 24 h for 5 days.
Complicated UTIs caused by Enterococcus faecalis, Enterococcus cloacae, E. coli, K. pneumoniae, P. mirabilis, or Pseudomonas aeruginosa, and for acute pyelonephritis caused by E. coli - 250 mg every 24 h for 10 days.

Complicated Skin and Skin Structure Infections; Nosocomial Pneumonia
Adults - PO / IV 750 mg every 24 h for 7 to 14 days.

Uncomplicated Skin and Skin Structure Infections
Adults - PO / IV 500 mg every 24 h for 7 to 10 days.

Uncomplicated UTIs
Adults - PO / IV 250 mg every 24 h for 3 days.

Bacterial Conjunctivitis
Adults and children 1 yr of age and older - Quixin - Days 1 and 2 - Topical Instill 1 to 2 drops in affected eye(s) every 2 h while awake, up to 8 times daily.
Days 3 through 7 - Topical Instill 1 to 2 drops in affected eye(s) every 4 h while awake, up to 4 times daily.
Iquix - Days 1 through 3 - Topical Instill 1 to 2 drops in the affected eye(s) every 30 min to 2 h while awake and approximately 4 and 6 h after retiring.
Days 4 through treatment completion - Topical Instill 1 or 2 drops in the affected eye(s) every 1 to 4 h while awake.

Cipro:

Acute Sinusitis
Adults - Mild/Moderate - PO 500 mg or IV 400 mg every 12 h for 10 days.

Acute Uncomplicated Pyelonephritis ( Cipro XR )
Adults - PO 1,000 mg every 24 h for 7 to 14 days.

Bone and Joint Infections
Adults - Mild/Moderate - PO 500 mg or IV 400 mg every 12 h for at least 4 to 6 wk.
Severe/Complicated - PO 750 mg every 12 h or IV 400 mg every 8 h for at least 4 to 6 wk.

Chronic Bacterial Prostatitis
Adults - Mild/Moderate - PO 500 mg or IV 400 mg every 12 h for 28 days.

Empirical Therapy for Febrile Neutropenic Patients
Adults - Severe - IV ciprofloxacin 400 mg every 8 h plus piperacillin 50 mg/kg (not to exceed 24 g/day) every 4 h for 7 to 14 days.

Infectious Diarrhea
Adults - Mild/Moderate/Severe - PO 500 mg every 12 h for 5 to 7 days.

Inhalational Anthrax (Postexposure)
Adults - PO 500 mg or IV 400 mg every 12 h for 60 days.
Children - PO 15 mg/kg/dose (max, 500 mg dose) or IV 10 mg/kg/dose (max, 400 mg dose) every 12 h for 60 days.

Intra-Abdominal Infections
Adults - Complicated - PO 500 mg or IV 400 mg every 12 h for 7 to 14 days in combination with metronidazole.

Lower Respiratory Tract Infections
Adults - Mild/Moderate - PO 500 mg or IV 400 mg every 12 h for 7 to 14 days.
Severe/Complicated - PO 750 mg every 12 h or IV 400 mg every 8 h for 7 to 14 days.

Nosocomial Pneumonia
Adults - Mild/Moderate/Severe - IV 400 mg every 8 h for 10 to 14 days.

Ocular Infections
Corneal ulcers - Solution Day 1: 2 drops in affected eye every 15 min for 6 h, then 2 drops every 30 min for remainder of day 1. Day 2: 2 drops every hour. Days 3 through 14: 2 drops every 4 h. May continue treatment after 14 days if corneal re-epithelialization has not occurred.
Conjunctivitis - Ointment Apply half-inch ribbon into conjunctival sac 3 times daily for the first 2 days, then twice daily for the next 5 days. Solution 1 to 2 drops every 2 h while awake for 2 days, then 1 to 2 drops every 4 h while awake for 5 days.

Otitis Externa
Adults and Children 1 yr of age and older - Otic - Instill the contents of 1 single-use container (deliverable volume, 0.25 mL) into the affected ear twice daily (approximately 12 h apart) for 7 days.

Skin and Skin Structure Infections
Adults - Mild/Moderate - PO 500 mg or IV 400 mg every 12 h for 7 to 14 days.
Severe/Complicated - PO 750 mg every 12 h or IV 400 mg every 8 h for 7 to 14 days.

Typhoid Fever
Adults - Mild/Moderate - PO 500 mg every 12 h for 10 days.

Urethral/Cervical Gonococcal Infections
Adults - Uncomplicated - PO 250 mg as a single dose.

UTIs
Adults - Acute uncomplicated - PO 250 mg every 12 h for 3 days. For Cipro XR, PO 500 mg every 24 h for 3 days. For Proquin XR, PO 500 mg once daily for 3 days.
Mild/Moderate - PO 250 mg or IV 200 mg every 12 h for 7 to 14 days.
Severe/Complicated - PO 500 mg or IV 400 mg every 12 h for 7 to 14 days. For Cipro XR, PO 1,000 mg every 24 h for 7 to 14 days.

Complicated UTI or Pyelonephritis
Children 1 to 17 yr of age - PO 10 to 20 mg/kg every 12 h (max, 750 mg/dose, even in patients weighing more than 51 kg) or IV 6 to 10 mg/kg every 8 h (max, 400 mg/dose, even in patients weighing more than 51 kg) for 10 to 21 days.

Renal Function Impairment
Adults - PO - Immediate-release/oral suspension - Usual dosage for CrCl more than 50 mL/min; 250 to 500 mg every 12 h for CrCl 30 to 50 mL/min; 250 to 500 mg every 18 h for CrCl 5 to 29 mL/min; 250 to 500 mg every 24 h (after dialysis) for patients on peritoneal or hemodialysis.
Cipro XR - Usual dosage for patients receiving 500 mg tablets; for CrCl less than 30 mL/min, max dose is 500 mg every 24 h. For patients on dialysis, administer dose after dialysis procedure is complete.
Proquin XR - No dosage adjustment is needed for patients with mild to moderate renal function impairment.
IV - Usual dosage for CrCl more than 30 mL/min; 200 to 400 mg every 18 to 24 h for CrCl 5 to 29 mL/min.

General Administration
Conversion of IV to Oral Dosing With Immediate-Release Tablets or Suspension in Adults

• 200 mg IV every 12 h equivalent to 250 mg orally every 12 h; 400 mg IV every 12 h equivalent to 500 mg orally every 12 h; 400 mg IV every 8 h equivalent to 750 mg orally every 12 h.